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技術文章(zhang)2024
3-252024
3-222024
3-192024
2-26精確捕捉神經活動的瞬間:神經元超微鈣成像系統的創新設計與實踐
在神(shen)(shen)(shen)經(jing)(jing)科學領(ling)域,對(dui)(dui)神(shen)(shen)(shen)經(jing)(jing)元(yuan)(yuan)(yuan)活(huo)(huo)(huo)動(dong)(dong)(dong)進(jin)(jin)行(xing)實時(shi)、精準(zhun)的(de)(de)(de)監測是一項至(zhi)關重要(yao)的(de)(de)(de)任務(wu)。近年來,一種(zhong)名(ming)為神(shen)(shen)(shen)經(jing)(jing)元(yuan)(yuan)(yuan)超微鈣(gai)成(cheng)像的(de)(de)(de)技術應運而生,它憑(ping)借其特別的(de)(de)(de)創(chuang)新設(she)計(ji)和先進(jin)(jin)的(de)(de)(de)實踐應用,成(cheng)功實現了對(dui)(dui)單(dan)個神(shen)(shen)(shen)經(jing)(jing)元(yuan)(yuan)(yuan)乃至(zhi)整(zheng)個神(shen)(shen)(shen)經(jing)(jing)網絡活(huo)(huo)(huo)動(dong)(dong)(dong)的(de)(de)(de)瞬(shun)態(tai)細節(jie)捕捉。神(shen)(shen)(shen)經(jing)(jing)元(yuan)(yuan)(yuan)超微鈣(gai)成(cheng)像系統的(de)(de)(de)核心原理是利用特定熒(ying)光染料對(dui)(dui)細胞(bao)內(nei)鈣(gai)離(li)(li)子(zi)濃(nong)度變(bian)化(hua)(hua)的(de)(de)(de)敏感性。當神(shen)(shen)(shen)經(jing)(jing)元(yuan)(yuan)(yuan)活(huo)(huo)(huo)動(dong)(dong)(dong)時(shi),細胞(bao)內(nei)部的(de)(de)(de)鈣(gai)離(li)(li)子(zi)濃(nong)度會迅速上升(sheng),通過(guo)加載具(ju)有鈣(gai)離(li)(li)子(zi)指示(shi)功能的(de)(de)(de)熒(ying)光探(tan)針,這些微小(xiao)的(de)(de)(de)鈣(gai)離(li)(li)子(zi)波(bo)動(dong)(dong)(dong)即可(ke)轉化(hua)(hua)為可(ke)被顯微鏡捕捉到的(de)(de)(de)熒(ying)光強度變(bian)化(hua)(hua)。因此,該技術能直觀反映出神(shen)(shen)(shen)經(jing)(jing)元(yuan)(yuan)(yuan)活(huo)(huo)(huo)動(dong)(dong)(dong)的(de)(de)(de)...2024
2-212024
1-302024
1-302024
1-22多通道電生理記錄刺激系統如何幫助科學家研究動物行為與神經活動之間的關系?
動(dong)(dong)(dong)物(wu)行為(wei)是動(dong)(dong)(dong)物(wu)神(shen)經(jing)(jing)系(xi)統(tong)(tong)(tong)(tong)活動(dong)(dong)(dong)的(de)(de)(de)外部表現(xian),而(er)神(shen)經(jing)(jing)活動(dong)(dong)(dong)是控制和(he)驅(qu)動(dong)(dong)(dong)動(dong)(dong)(dong)物(wu)行為(wei)的(de)(de)(de)內在(zai)機(ji)制。了(le)解動(dong)(dong)(dong)物(wu)行為(wei)與(yu)神(shen)經(jing)(jing)活動(dong)(dong)(dong)之間的(de)(de)(de)關系(xi)對于理(li)解動(dong)(dong)(dong)物(wu)行為(wei)背后的(de)(de)(de)神(shen)經(jing)(jing)基(ji)礎和(he)認知過程至關重要。在(zai)這(zhe)方面,多(duo)通(tong)(tong)道電(dian)生理(li)記(ji)錄刺(ci)激系(xi)統(tong)(tong)(tong)(tong)發揮(hui)著重要作用。該(gai)系(xi)統(tong)(tong)(tong)(tong)可以實時(shi)記(ji)錄動(dong)(dong)(dong)物(wu)大腦(nao)中的(de)(de)(de)神(shen)經(jing)(jing)元(yuan)活動(dong)(dong)(dong),幫助科學(xue)家觀(guan)察(cha)和(he)分析(xi)不同(tong)區域(yu)的(de)(de)(de)神(shen)經(jing)(jing)元(yuan)如(ru)何參與(yu)特定(ding)行為(wei)。通(tong)(tong)過將多(duo)個電(dian)極植入(ru)動(dong)(dong)(dong)物(wu)的(de)(de)(de)大腦(nao)組(zu)織中,這(zhe)種系(xi)統(tong)(tong)(tong)(tong)能(neng)夠同(tong)時(shi)監測到(dao)多(duo)個神(shen)經(jing)(jing)元(yuan)的(de)(de)(de)電(dian)活動(dong)(dong)(dong),從而(er)提供(gong)了(le)高時(shi)空分辨(bian)率(lv)的(de)(de)(de)神(shen)經(jing)(jing)活動(dong)(dong)(dong)數據。利(li)用該(gai)系(xi)統(tong)(tong)(tong)(tong),科學(xue)家可以追(zhui)蹤(zong)和(he)記(ji)錄動(dong)(dong)(dong)物(wu)在(zai)不同(tong)行為(wei)任務下的(de)(de)(de)神(shen)...2024
1-162023
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